Malaria in pregnancy regulates P‐glycoprotein (P‐gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac

Malaria in pregnancy (MiP) induces intrauterine growth restriction (IUGR) and preterm labour (PTL). However, its effects on yolk sac morphology and function are largely unexplored. We hypothesized that MiP modifies yolk sac morphology and efflux transport potential by modulating ABC efflux transport...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular and molecular medicine 2020-09, Vol.24 (18), p.10636-10647
Hauptverfasser:	Martinelli, Lilian M., Fontes, Klaus N., Reginatto, Mila W., Andrade, Cherley B. V., Monteiro, Victoria R. S., Gomes, Hanailly R., Silva‐Filho, Joao L., Pinheiro, Ana A. S., Vago, Annamaria R., Almeida, Fernanda R. C. L., Bloise, Flavia F., Matthews, Stephen G., Ortiga‐Carvalho, Tania M., Bloise, Enrrico
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters ABCA1 ABCA1 protein ABCG1 Animals ATP Binding Cassette Transporter 1 - biosynthesis ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter, Subfamily B - biosynthesis ATP Binding Cassette Transporter, Subfamily B - genetics ATP-binding protein Biological Transport Birth weight Blood vessels Breast cancer Breast Cancer Resistance Protein (BCRP) Cell Biology Cell membranes Chemokines Cytokines Cytokines - biosynthesis Cytokines - genetics Cytoplasm Endothelium Epithelium Erythrocytes Female Fetal Growth Retardation - etiology Fetuses Gene expression Gene Expression Regulation Glycoproteins Immunohistochemistry Infections Inflammation Interleukin 6 Labeling Laboratory animals Leukocyte migration Life Sciences & Biomedicine Macrophage migration inhibitory factor Malaria Malaria - complications Malaria - genetics Malaria - metabolism malaria in pregnancy (MiP) Medicine, Research & Experimental Membrane Transport Proteins - biosynthesis Membrane Transport Proteins - genetics Mesothelium Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 Morphology Nutrients Organ Size Original P-Glycoprotein Plasmodium berghei Plasmodium berghei ANKA Pregnancy Pregnancy Complications, Infectious - genetics Pregnancy Complications, Infectious - metabolism Proteins P‐glycoprotein (P‐gp) Research & Experimental Medicine RNA, Messenger - biosynthesis RNA, Messenger - genetics Science & Technology Xenobiotics Yolk Yolk sac Yolk Sac - metabolism Yolk Sac - ultrastructure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Malaria in pregnancy (MiP) induces intrauterine growth restriction (IUGR) and preterm labour (PTL). However, its effects on yolk sac morphology and function are largely unexplored. We hypothesized that MiP modifies yolk sac morphology and efflux transport potential by modulating ABC efflux transporters. C57BL/6 mice injected with Plasmodium berghei ANKA (5 × 105 infected erythrocytes) at gestational day (GD) 13.5 were subjected to yolk sac membrane harvesting at GD 18.5 for histology, qPCR and immunohistochemistry. MiP did not alter the volumetric proportion of the yolk sac's histological components. However, it increased levels of Abcb1a mRNA (encoding P‐glycoprotein) and macrophage migration inhibitory factor (Mif chemokine), while decreasing Abcg1 (P
ISSN:	1582-1838 1582-4934
DOI:	10.1111/jcmm.15682