N on‐ A lcoholic F atty L iver D isease ( NAFLD ) in children and adolescents with P rader– W illi S yndrome ( PWS )

We tested the hypothesis that patients with P rader– W illi syndrome ( PWS ) may be at lower risk of developing non‐alcoholic fatty liver disease ( NAFLD ) because of a higher insulin sensitivity. Twenty‐one PWS patients and 42 control subjects closely similar for age, gender, pubertal stage and body mass index ( CNT ), were studied. Metabolic profile and body composition were assessed. NAFLD was established by a validated method of US grading (range from G 0 to G 3). PWS patients showed a significantly better metabolic profile (lower waist circumference, fasting glucose levels, HOMA ‐ IR , cholesterol, transaminase levels and trunk fat mass/fat mass ratio). Furthermore, NAFLD G 1stage was significantly more frequent in PWS subjects ( P