Association of the HLA ‐B27 antigen and the CTLA 4 gene CT 60/rs3087243 polymorphism with ankylosing spondylitis in Algerian population: A case–control study
Ankylosing spondylitis ( AS ) is a complex inflammatory disease that represents a major health problem both in Algeria and worldwide. Several lines of evidence support that genetic risk factors play a role in AS etiology and the CTLA 4 gene has attracted a considerable attention. In this study, we w...
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Veröffentlicht in: | International journal of immunogenetics 2018-06, Vol.45 (3), p.109-117 |
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Sprache: | eng |
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Zusammenfassung: | Ankylosing spondylitis (
AS
) is a complex inflammatory disease that represents a major health problem both in Algeria and worldwide. Several lines of evidence support that genetic risk factors play a role in
AS
etiology and the
CTLA
4
gene has attracted a considerable attention. In this study, we were interested in evaluating the
HLA
‐B27
frequency and in exploring the
CTLA
4
gene in a sample of the North African population. The dataset of the current study is composed of 81 patients with
AS
and 123 healthy controls. All samples were genotyped by TaqMan
®
allelic discrimination assay. The genetic risk of the
HLA
‐B27
specificity and the
CTLA
4/
CT
60
polymorphism were assessed by odds ratios (
OR
) with 95% confidence intervals (
CI
). High spondylitis risk was detected for
HLA
‐B27
allele (
OR
= 14.62,
p
=
10
−6
) in addition to a significant association of the
CT
60
*G allele (
OR
= 1.89,
p
=
.002). After gender and age stratifications, the association of the
CT
60
*G allele was still significant in females sample (
OR
= 2.10,
p
=
.001) and when age up to 30 years (
OR
= 2.21,
p
=
.008). Interestingly, the
CT
60
*G allele revealed an increased spondylitis risk in the B27 negative group (
OR
= 2.81,
p
=
.006). The present work showed in West Algerian population that the
HLA
‐B27
antigen and the variation in the
CTLA
4
3′
UTR
region played an important role in the ankylosing spondylitis susceptibility. The heterogeneity of this disease is deduced by genetic difference found between B27+ and B27− groups. |
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ISSN: | 1744-3121 1744-313X |
DOI: | 10.1111/iji.12369 |