Susceptible and protective associations of HLA DRB 1/ DQB 1 alleles and haplotypes with ischaemic stroke
Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen ( HLA )‐ DRB 1*/ DQB 1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke...
Gespeichert in:
Veröffentlicht in: | International journal of immunogenetics 2016-06, Vol.43 (3), p.159-165 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Stroke has emerged as the second commonest cause of mortality worldwide and is a major public health problem. For the first time, we present here the association of human leucocyte antigen (
HLA
)‐
DRB
1*/
DQB
1* alleles and haplotypes with ischaemic stroke in South Indian patients. Ischaemic stroke (
IS
) cases and controls were genotyped for
HLA
‐
DRB
1*/
DQB
1* alleles by polymerase chain reaction sequence‐specific primers (
PCR
‐
SSP
) method. The frequencies of
HLA
class
II
alleles such as
DRB
1*04,
DRB
1*07,
DRB
1*11,
DRB
1*12,
DRB
1*13,
DQB
1*02 and
DQB
1*07 were high in
IS
patients than in the age‐ and gender‐matched controls, suggesting that the individuals with these alleles are susceptible to ischaemic stroke in South India. The frequencies of alleles such as
DRB
1*03,
DRB
1*10,
DRB
1*14,
DQB
1*04 and
DQB
1*05 were less in
IS
cases than in the controls, suggesting a protective association. Haplotypes
DRB
1*04‐
DQB
1*0301,
DRB
1*07‐
DQB
1*02,
DRB
1*07‐
DQB
1*0301,
DRB
1*11‐
DQB
1*0301 and
DRB
1*13‐
DQB
1*06 were found to be high in
IS
patients conferring susceptibility. The frequency of haplotype
DRB
1*10‐
DQB
1*05 was high in controls conferring protection.
IS
‐
LVD
and gender‐stratified analysis too confirmed these susceptible and protective associations.
Thus, HLA
‐
DRB
1*/
DQB
1* alleles and haplotypes strongly predispose South Indian population to ischaemic stroke. Further studies in different populations with large sample size or the meta‐analysis are needed to explain the exact mechanism of associations of
HLA
gene(s) with
IS
. |
---|---|
ISSN: | 1744-3121 1744-313X |
DOI: | 10.1111/iji.12266 |