Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing: three clinical studies

Objective Vitamin C and peptides are widely used in cosmetic products but there is a paucity of clinical studies showing that the formulations are effective in treating signs of facial ageing. These 3 clinical studies evaluated the effectiveness of an anti‐ageing formula containing natural vitamin C (10%), biopeptides (rice and lupin), hyaluronic acid, and Vichy volcanic mineralising water, in amber glass ampoules with no preservatives (Peptide‐C ampoules). Methods Dansyl chloride fluorescence labelling compared cell turnover for Peptide‐C ampoules vs untreated skin in 32 female subjects. Study 2, an open clinical study, evaluated the efficacy on wrinkles of Peptide‐C ampoules by investigator clinical scoring based on Dynamical Atlas visual assessment (N = 40) and subject self‐assessment questionnaires (N = 47). Study 3, an open clinical study, evaluated wrinkles by instrumental quantification with 3D fringe projection analysis (N = 40) and subject questionnaires (N = 51). Results The mean cell turnover was faster for skin treated with Peptide‐C ampoules compared to untreated skin (17.1 days vs. 19.2 days; P