LRP 1/ CD 91 is up‐regulated in monocytes from patients with haemophilia A: a single‐centre analysis

The low‐density lipoprotein receptor‐related protein 1 ( LRP 1) is an ubiquitously expressed endocytic receptor that, among its several functions, is involved in the catabolism of coagulation factor VIII ( FVIII ) and in the regulation of its plasma concentrations. Although LRP 1/ CD 91 polymorphisms have been associated with increased FVIII levels and a consequent thrombotic risk, no data are available on LRP 1/ CD 91 expression in patients with inherited FVIII deficiency. With the aim of elucidating this issue, 45 consecutive patients with haemophilia A ( HA ) (18 severe, 5 moderate and 22 mild HA ) were enrolled in this cross‐sectional, single‐centre survey. The LRP 1/ CD 91 mean fluorescence intensity ( MFI ) in monocytes from HA patients was significantly higher than that detected in 90 healthy blood donors (105 vs. 67, P