The association between ST 18 gene polymorphism and severe pemphigus disease among Iranian population

Recently, ST 18 polymorphism has played a role in increasing the risk of pemphigus among some populations such as Egyptian and Jewish. In addition, a variant within the ST 18 promoter gene was shown to induce ST 18 upregulation and cytokine secretion leading to keratinocyte susceptibility to anti‐desmoglein antibodies. Thus, the present study aimed to assess the ST 18 single nucleotide polymorphisms ( SNP ) relationship with pemphigus, disease severity and family history among Iranian population. A total of 111 pemphigus patients and 201 healthy controls were genotyped for three ST 18 SNP s rs2304365, rs10504140 and rs4074067 by using TETRA ‐ ARMS PCR method. The results indicated that risk allele A in rs2304365 was significantly higher in pemphigus patients, compared with the amount in the control group ( OR = 2.43 CI = 1.49‐3.975, P