Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis
Introduction Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS. Methods Two hundre...
Gespeichert in:
| Veröffentlicht in: | Echocardiography (Mount Kisco, N.Y.) N.Y.), 2020-11, Vol.37 (11), p.1732-1740 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1740 |
|---|---|
| container_issue | 11 |
| container_start_page | 1732 |
| container_title | Echocardiography (Mount Kisco, N.Y.) |
| container_volume | 37 |
| creator | Gamaza, Sergio Díaz‐Retamino, Enrique Gaitero, José Carlos Giráldez, Alberto Zafra, Francisco Manuel Martín‐Santana, Antonio Oneto, Jesús |
| description | Introduction
Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS.
Methods
Two hundred and twenty‐five patients with at least moderate AS (effective orifice area [EOA] ≤ 1.50 cm2) were prospectively enrolled. EOA was normalized to body surface area (BSA), height, and body mass index (BMI). Receiver operating characteristic curves, in women and men separately, were plotted to determine the best cutoff value for predicting cardiovascular death.
Results
The largest area under the curve (AUC) to predict cardiovascular death was EOA in men (AUC 0.74, P |
| doi_str_mv | 10.1111/echo.14868 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1111_echo_14868</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2452097076</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2888-5cc4caf5e6901b8f1e4aa3ea86b0cdce00af2bfd47891db62f920481250dd8143</originalsourceid><addsrcrecordid>eNqN0c1q3DAQB3ARGpLNx6UPUHQsCU5GsmzLx2LyBYG9JGcjyyOqYltbSW6zPfUR-ox9kmiz2z2W6CIN_GYY_iLkI4Mrls416q_uiglZygOyYIWATLKq-EAWUAmeccn5MTkJ4RsAVIyJI3Kc51BBLssFMcs5ajciteNqsFpF6ybqDA348vf3H4-DithTNAZ1tD-QOm-N1UiVR0Un50c12F9JREc7169pSBW1E1XOR6tpiDi5YMMZOTRqCHi-u0_J8-3NU3OfPS7vHpovj5nmUsqs0FpoZQosa2CdNAyFUjkqWXage40AyvDO9KKSNeu7kpuag5CMF9D3kon8lHzezl15933GENvRBo3DoCZ0c2i5KDjUFVRlohdbqr0LwaNpV96Oyq9bBu0m13aTa_uWa8KfdnPnbsR-T_8FmcDlFvzEzpmgLU4a9ywlX1R1IaVIL2BJy_frxsa3b2ncPMXUynatdsD1f3Zub5r75Xb7V868plg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2452097076</pqid></control><display><type>article</type><title>Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis</title><source>Access via Wiley Online Library</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Gamaza, Sergio ; Díaz‐Retamino, Enrique ; Gaitero, José Carlos ; Giráldez, Alberto ; Zafra, Francisco Manuel ; Martín‐Santana, Antonio ; Oneto, Jesús</creator><creatorcontrib>Gamaza, Sergio ; Díaz‐Retamino, Enrique ; Gaitero, José Carlos ; Giráldez, Alberto ; Zafra, Francisco Manuel ; Martín‐Santana, Antonio ; Oneto, Jesús</creatorcontrib><description>Introduction
Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS.
Methods
Two hundred and twenty‐five patients with at least moderate AS (effective orifice area [EOA] ≤ 1.50 cm2) were prospectively enrolled. EOA was normalized to body surface area (BSA), height, and body mass index (BMI). Receiver operating characteristic curves, in women and men separately, were plotted to determine the best cutoff value for predicting cardiovascular death.
Results
The largest area under the curve (AUC) to predict cardiovascular death was EOA in men (AUC 0.74, P < .001) and EOA/height in women (AUC 0.81, P < .001). An EOA/height cutoff value of 0.55 cm2/m in women had a sensitivity of 100% and specificity of 61%; a cutoff of 0.50 cm2/m in men obtained a sensitivity of 92% and a specificity of 56%. During a mean follow‐up of 247 ± 183 days, there were 33 cardiovascular deaths. Women with EOA/height ≤ 0.55 cm2/m had higher cardiovascular mortality (22% vs 0%, P < .001) and men with EOA/height ≤ 0.50 cm2/m (21% vs 2%, P < .001). One‐year survival in women with EOA/height ≤ 0.55 cm2/m was 67 ± 8% and 100 ± 0% in EOA/height > 0.55 cm2/m (P < .001). In men, 1‐year survival was 70 ± 8% in EOA/height ≤ 0.50 cm2/m, and 93 ± 6% in EOA/height > 0.50 cm2/m (P = .004).
Conclusions
Normalization of EOA is useful in AS, especially in women. We recommend using an EOA/height cutoff value of 0.55 cm2/m in women, and 0.50 cm2/m in men to identify a subgroup with higher cardiovascular risk.</description><identifier>ISSN: 0742-2822</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.14868</identifier><identifier>PMID: 33070386</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>aortic stenosis ; Cardiac & Cardiovascular Systems ; Cardiovascular System & Cardiology ; echocardiography ; gender ; Life Sciences & Biomedicine ; prognosis ; Science & Technology</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2020-11, Vol.37 (11), p.1732-1740</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000579588400001</woscitedreferencesoriginalsourcerecordid><cites>FETCH-LOGICAL-c2888-5cc4caf5e6901b8f1e4aa3ea86b0cdce00af2bfd47891db62f920481250dd8143</cites><orcidid>0000-0003-2454-155X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.14868$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.14868$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,28252,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33070386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gamaza, Sergio</creatorcontrib><creatorcontrib>Díaz‐Retamino, Enrique</creatorcontrib><creatorcontrib>Gaitero, José Carlos</creatorcontrib><creatorcontrib>Giráldez, Alberto</creatorcontrib><creatorcontrib>Zafra, Francisco Manuel</creatorcontrib><creatorcontrib>Martín‐Santana, Antonio</creatorcontrib><creatorcontrib>Oneto, Jesús</creatorcontrib><title>Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>ECHOCARDIOGR-J CARD</addtitle><addtitle>Echocardiography</addtitle><description>Introduction
Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS.
Methods
Two hundred and twenty‐five patients with at least moderate AS (effective orifice area [EOA] ≤ 1.50 cm2) were prospectively enrolled. EOA was normalized to body surface area (BSA), height, and body mass index (BMI). Receiver operating characteristic curves, in women and men separately, were plotted to determine the best cutoff value for predicting cardiovascular death.
Results
The largest area under the curve (AUC) to predict cardiovascular death was EOA in men (AUC 0.74, P < .001) and EOA/height in women (AUC 0.81, P < .001). An EOA/height cutoff value of 0.55 cm2/m in women had a sensitivity of 100% and specificity of 61%; a cutoff of 0.50 cm2/m in men obtained a sensitivity of 92% and a specificity of 56%. During a mean follow‐up of 247 ± 183 days, there were 33 cardiovascular deaths. Women with EOA/height ≤ 0.55 cm2/m had higher cardiovascular mortality (22% vs 0%, P < .001) and men with EOA/height ≤ 0.50 cm2/m (21% vs 2%, P < .001). One‐year survival in women with EOA/height ≤ 0.55 cm2/m was 67 ± 8% and 100 ± 0% in EOA/height > 0.55 cm2/m (P < .001). In men, 1‐year survival was 70 ± 8% in EOA/height ≤ 0.50 cm2/m, and 93 ± 6% in EOA/height > 0.50 cm2/m (P = .004).
Conclusions
Normalization of EOA is useful in AS, especially in women. We recommend using an EOA/height cutoff value of 0.55 cm2/m in women, and 0.50 cm2/m in men to identify a subgroup with higher cardiovascular risk.</description><subject>aortic stenosis</subject><subject>Cardiac & Cardiovascular Systems</subject><subject>Cardiovascular System & Cardiology</subject><subject>echocardiography</subject><subject>gender</subject><subject>Life Sciences & Biomedicine</subject><subject>prognosis</subject><subject>Science & Technology</subject><issn>0742-2822</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqN0c1q3DAQB3ARGpLNx6UPUHQsCU5GsmzLx2LyBYG9JGcjyyOqYltbSW6zPfUR-ox9kmiz2z2W6CIN_GYY_iLkI4Mrls416q_uiglZygOyYIWATLKq-EAWUAmeccn5MTkJ4RsAVIyJI3Kc51BBLssFMcs5ajciteNqsFpF6ybqDA348vf3H4-DithTNAZ1tD-QOm-N1UiVR0Un50c12F9JREc7169pSBW1E1XOR6tpiDi5YMMZOTRqCHi-u0_J8-3NU3OfPS7vHpovj5nmUsqs0FpoZQosa2CdNAyFUjkqWXage40AyvDO9KKSNeu7kpuag5CMF9D3kon8lHzezl15933GENvRBo3DoCZ0c2i5KDjUFVRlohdbqr0LwaNpV96Oyq9bBu0m13aTa_uWa8KfdnPnbsR-T_8FmcDlFvzEzpmgLU4a9ywlX1R1IaVIL2BJy_frxsa3b2ncPMXUynatdsD1f3Zub5r75Xb7V868plg</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Gamaza, Sergio</creator><creator>Díaz‐Retamino, Enrique</creator><creator>Gaitero, José Carlos</creator><creator>Giráldez, Alberto</creator><creator>Zafra, Francisco Manuel</creator><creator>Martín‐Santana, Antonio</creator><creator>Oneto, Jesús</creator><general>Wiley</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2454-155X</orcidid></search><sort><creationdate>202011</creationdate><title>Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis</title><author>Gamaza, Sergio ; Díaz‐Retamino, Enrique ; Gaitero, José Carlos ; Giráldez, Alberto ; Zafra, Francisco Manuel ; Martín‐Santana, Antonio ; Oneto, Jesús</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2888-5cc4caf5e6901b8f1e4aa3ea86b0cdce00af2bfd47891db62f920481250dd8143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>aortic stenosis</topic><topic>Cardiac & Cardiovascular Systems</topic><topic>Cardiovascular System & Cardiology</topic><topic>echocardiography</topic><topic>gender</topic><topic>Life Sciences & Biomedicine</topic><topic>prognosis</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gamaza, Sergio</creatorcontrib><creatorcontrib>Díaz‐Retamino, Enrique</creatorcontrib><creatorcontrib>Gaitero, José Carlos</creatorcontrib><creatorcontrib>Giráldez, Alberto</creatorcontrib><creatorcontrib>Zafra, Francisco Manuel</creatorcontrib><creatorcontrib>Martín‐Santana, Antonio</creatorcontrib><creatorcontrib>Oneto, Jesús</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gamaza, Sergio</au><au>Díaz‐Retamino, Enrique</au><au>Gaitero, José Carlos</au><au>Giráldez, Alberto</au><au>Zafra, Francisco Manuel</au><au>Martín‐Santana, Antonio</au><au>Oneto, Jesús</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><stitle>ECHOCARDIOGR-J CARD</stitle><addtitle>Echocardiography</addtitle><date>2020-11</date><risdate>2020</risdate><volume>37</volume><issue>11</issue><spage>1732</spage><epage>1740</epage><pages>1732-1740</pages><issn>0742-2822</issn><eissn>1540-8175</eissn><abstract>Introduction
Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS.
Methods
Two hundred and twenty‐five patients with at least moderate AS (effective orifice area [EOA] ≤ 1.50 cm2) were prospectively enrolled. EOA was normalized to body surface area (BSA), height, and body mass index (BMI). Receiver operating characteristic curves, in women and men separately, were plotted to determine the best cutoff value for predicting cardiovascular death.
Results
The largest area under the curve (AUC) to predict cardiovascular death was EOA in men (AUC 0.74, P < .001) and EOA/height in women (AUC 0.81, P < .001). An EOA/height cutoff value of 0.55 cm2/m in women had a sensitivity of 100% and specificity of 61%; a cutoff of 0.50 cm2/m in men obtained a sensitivity of 92% and a specificity of 56%. During a mean follow‐up of 247 ± 183 days, there were 33 cardiovascular deaths. Women with EOA/height ≤ 0.55 cm2/m had higher cardiovascular mortality (22% vs 0%, P < .001) and men with EOA/height ≤ 0.50 cm2/m (21% vs 2%, P < .001). One‐year survival in women with EOA/height ≤ 0.55 cm2/m was 67 ± 8% and 100 ± 0% in EOA/height > 0.55 cm2/m (P < .001). In men, 1‐year survival was 70 ± 8% in EOA/height ≤ 0.50 cm2/m, and 93 ± 6% in EOA/height > 0.50 cm2/m (P = .004).
Conclusions
Normalization of EOA is useful in AS, especially in women. We recommend using an EOA/height cutoff value of 0.55 cm2/m in women, and 0.50 cm2/m in men to identify a subgroup with higher cardiovascular risk.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>33070386</pmid><doi>10.1111/echo.14868</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2454-155X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-2822 |
| ispartof | Echocardiography (Mount Kisco, N.Y.), 2020-11, Vol.37 (11), p.1732-1740 |
| issn | 0742-2822 1540-8175 |
| language | eng |
| recordid | cdi_crossref_primary_10_1111_echo_14868 |
| source | Access via Wiley Online Library; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | aortic stenosis Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology echocardiography gender Life Sciences & Biomedicine prognosis Science & Technology |
| title | Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T17%3A05%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Outcome%20implication%20of%20sex%E2%80%90related%20effective%20orifice%20area%20normalized%20to%20body%20size%20in%20aortic%20stenosis&rft.jtitle=Echocardiography%20(Mount%20Kisco,%20N.Y.)&rft.au=Gamaza,%20Sergio&rft.date=2020-11&rft.volume=37&rft.issue=11&rft.spage=1732&rft.epage=1740&rft.pages=1732-1740&rft.issn=0742-2822&rft.eissn=1540-8175&rft_id=info:doi/10.1111/echo.14868&rft_dat=%3Cproquest_cross%3E2452097076%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2452097076&rft_id=info:pmid/33070386&rfr_iscdi=true |