Outcome implication of sex‐related effective orifice area normalized to body size in aortic stenosis

Introduction Although several echocardiographic parameters have different values according to sex, there are no studies in echocardiographic variables of aortic stenosis (AS) severity. Our aim was to evaluate the sex‐related prognosis of several echocardiographic parameters in AS. Methods Two hundred and twenty‐five patients with at least moderate AS (effective orifice area [EOA] ≤ 1.50 cm2) were prospectively enrolled. EOA was normalized to body surface area (BSA), height, and body mass index (BMI). Receiver operating characteristic curves, in women and men separately, were plotted to determine the best cutoff value for predicting cardiovascular death. Results The largest area under the curve (AUC) to predict cardiovascular death was EOA in men (AUC 0.74, P