Early anthracycline‐induced cardiotoxicity monitored by echocardiographic Doppler parameters combined with serum hs‐cTnT

Purpose As growing numbers of long‐term cancer survivors faced with the cardiac side effects by anthracycline treatment, it is necessary to explore the optimal monitoring method for the early detection of cardiac toxicity. Methods We conducted a retrospective analysis of 82 consecutive patients with diffuse large B‐cell lymphoma treated with chemotherapy. Echocardiographic Doppler imaging‐derived Tei index and mitral annular peak systolic velocity (Sm) measured by tissue Doppler imaging TDI, serum high‐sensitivity cardiac troponin T (hs‐cTnT) levels, and left ventricular ejection fraction (LVEF) by multigated radionuclide angiography (MUGA) were obtained before, after 2–4, and after 6–8 chemotherapy cycles. Cardiotoxicity was defined as a relative reduction of LVEF ≥10% from the baseline or LVEF