Associations between HbA 1c and continuous glucose monitoring-derived glycaemic variables

To identify clinically useful associations between HbA levels and various continuous glucose monitoring-derived metrics. We retrospectively analysed end-of-study HbA levels and >2 weeks of continuous glucose monitoring data collected from 530 adults with Type 1 diabetes or insulin-requiring Type 2 diabetes during four randomized trials. Each trial lasted ≥24 weeks and provided central laboratory end-of-study HbA levels and continuous glucose monitoring data from the preceding 3 months. Participants were assigned to groups based on either HbA levels or continuous glucose monitoring-derived glucose values. HbA was strongly correlated with mean glucose value (r=0.80), time spent with glucose values in the 3.9-10.0 mmol/l range (time in range; r=-0.75) and percentage of glucose values >13.9 mmol/l (r=0.72), but was weakly correlated with the percentage of glucose values