Urinary WT 1‐positive cells as a non‐invasive biomarker of crescent formation

WT1 positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1 positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value...

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Veröffentlicht in:Cytopathology (Oxford) 2017-12, Vol.28 (6), p.524-530
Hauptverfasser: Fujita, T., Sofue, T., Moritoki, M., Nishijima, Y., Tokuhara, Y., Wakisaka, H., Kushida, Y., Haba, R., Ohsaki, H.
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container_end_page 530
container_issue 6
container_start_page 524
container_title Cytopathology (Oxford)
container_volume 28
creator Fujita, T.
Sofue, T.
Moritoki, M.
Nishijima, Y.
Tokuhara, Y.
Wakisaka, H.
Kushida, Y.
Haba, R.
Ohsaki, H.
description WT1 positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1 positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value of 5 cells/10 mL, WT1 positive urinary cells can be used to detect patients with crescentic formation.
doi_str_mv 10.1111/cyt.12460
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title Urinary WT 1‐positive cells as a non‐invasive biomarker of crescent formation
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