Urinary WT 1‐positive cells as a non‐invasive biomarker of crescent formation

WT1 positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1 positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value...

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Veröffentlicht in:Cytopathology (Oxford) 2017-12, Vol.28 (6), p.524-530
Hauptverfasser: Fujita, T., Sofue, T., Moritoki, M., Nishijima, Y., Tokuhara, Y., Wakisaka, H., Kushida, Y., Haba, R., Ohsaki, H.
Format: Artikel
Sprache:eng
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Zusammenfassung:WT1 positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1 positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value of 5 cells/10 mL, WT1 positive urinary cells can be used to detect patients with crescentic formation.
ISSN:0956-5507
1365-2303
DOI:10.1111/cyt.12460