Macular hole after intravitreal bevacizumab injection for choroidal neovascularisation

The aim of this study was to report a patient who developed a full-thickness macular hole following intravitreal bevacizumab injection. A 78-year-old patient diagnosed with choroidal neovascularisation (CNV) was treated with intravitreal bevacizumab injection. On the first follow-up visit, a decrease in visual acuity was seen and a small full-thickness macular hole with complete resolution of subretinal fluid was observed in optical coherence tomography (OCT). A second intravitreal injection of bevacizumab was performed. At the subsequent visit, a serious loss of visual acuity and limited regression in choroidal neovascularisation was seen. The OCT showed a larger full-thickness macular hole. This case demonstrates that intravitreal bevacizumab injection might be responsible for the development of a macular hole. Clinicians should be cautious that a macular hole may be a complication of intravitreal bevacizumab injection.