Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review
The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the enzyme causes postprandial hyperglycaemia and blood glucose levels to rise. α‐Amylase is a well‐known therapeutic target for...
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Veröffentlicht in: | Chemical biology & drug design 2021-10, Vol.98 (4), p.539-560 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The alpha (α)‐amylase is a calcium metalloenzyme that aids digestion by breaking down polysaccharide molecules into smaller ones such as glucose and maltose. In addition, the enzyme causes postprandial hyperglycaemia and blood glucose levels to rise. α‐Amylase is a well‐known therapeutic target for the treatment and maintenance of postprandial blood glucose elevations. Various enzymatic inhibitors, such as acarbose, miglitol and voglibose, have been found to be effective in targeting this enzyme, prompting researchers to express an interest in developing potent alpha‐amylase inhibitor molecules. The review mainly focused on designing different derivatives of drug molecules such as benzofuran hydrazone, indole hydrazone, spiroindolone, benzotriazoles, 1,3‐diaryl‐3‐(arylamino) propan‐1‐one, oxadiazole and flavonoids along with their target–receptor interactions, IC50 values and other biological activities.
This review mainly focused on alpha (α)‐ amylase as potential biological target for treatment of Diabetes mellitus, and summarized all the reported derivatives of different nucleus like benzofuran hydrazone, indole hydrazone, spiroindolone, benzotriazoles, 1,3 diaryl‐3‐(arylamino) propan‐1‐one, oxadiazole, flavonoids etc. All these possible derivatives will help researchers to develop new potent alpha amylase inhibitors in the future. |
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ISSN: | 1747-0277 1747-0285 |
DOI: | 10.1111/cbdd.13909 |