ATF 7 IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

We identified ATF 7 IP as a novel PDGFRB fusion partner in B‐progenitor acute lymphoblastic leukaemia (B‐ ALL ) and showed that B‐ ALL with ATF 7 IP / PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)‐like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B‐ ALL cases with high PDGFRB expression level in the context of the Ph‐like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph‐like ALL subgroup.