Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

Using samples from the New England Centenarian Study (NECS), we sought to characterize the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched controls of the offspring (mean ages: 105, 80, and 79 years). We identified 1312 proteins that significantly differ betwee...

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Veröffentlicht in:	Aging cell 2021-02, Vol.20 (2), p.e13290-n/a, Article 13290
Hauptverfasser:	Sebastiani, Paola, Federico, Anthony, Morris, Melody, Gurinovich, Anastasia, Tanaka, Toshiko, Chandler, Kevin B., Andersen, Stacy L., Denis, Gerald, Costello, Catherine E., Ferrucci, Luigi, Jennings, Lori, Glass, David J., Monti, Stefano, Perls, Thomas T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Aging Alzheimer's disease Analysis Biomarkers Blood proteins Blood Proteins - metabolism Cell Biology Cellular Senescence Centenarians DNA methylation Gene regulation Geriatrics Geriatrics & Gerontology Growth factors Health care Humans Insulin Life Sciences & Biomedicine Longevity Offspring Oldest old people Original Phenotypes Plasma protein Proteins Proteomes Science & Technology Senescence Serum proteins SomaLogic
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Zusammenfassung:	Using samples from the New England Centenarian Study (NECS), we sought to characterize the serum proteome of 77 centenarians, 82 centenarians' offspring, and 65 age‐matched controls of the offspring (mean ages: 105, 80, and 79 years). We identified 1312 proteins that significantly differ between centenarians and their offspring and controls (FDR
ISSN:	1474-9718 1474-9726
DOI:	10.1111/acel.13290