Blockchain and Machine Learning in EHR Security: A Systematic Review

Background: The rapid development of modern technologies renders a convenient and efficient solution to implement Electronic Health Records (EHRs) systems. The rapid growth of healthcare data has a distinctive attribute of digital transformations. The big datasets of healthcare, their complexity and their dynamic nature have posed severe challenges associated with the analysis, pre-processing, privacy, security, storage, usability and data exchange. Material and Methods: We have performed the Systematic Literature Review (SLR) and followed the Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology. SLR refers to the methodology that discovers, analyses and accesses recent research literature related to the subject field. The research papers were searched from academic repositories like IEEE, WOS, Scopus and PubMed for the previous five years on March 2023. Results: The designed search string provides 199 research articles in total. We filter the research articles based on inclusion-exclusion strategies and quality assessment metrics. Six main criteria for research inclusion-exclusion for SLR are formulated. These works of literature insight into 1) the issues associated with interoperability and security of EHRs by using the Blockchain (BC) technology, 2) different frameworks and tools to improve privacy and security in the healthcare domain, 3) the open issues of using BC technology in the electronic healthcare domain, 4) the standardized ways to store EHRs, 5) various ways to handle the big data using the BC systems and 6) the usage of Federated Learning (FL) to preserve the privacy of EHRs in the healthcare domain. We acquired 46 research articles based on the criteria (inclusion-exclusion) that investigate the above-mentioned issues. Conclusion: The SLR will serve as the state-of-the-art (SOTA) for future researchers in the field of BC in healthcare. Additionally, the paper provides insights to the new researchers to revolutionize the healthcare domain by adopting the latest digitalized technologies. The proposed study identified various reflections. It analyzed the architectural mechanism that supports the security and interoperability of EHRs. Secondly, the study described different tools and frameworks to improve the privacy and security of EHRs using the BC. Thirdly, the open issues of storing and preserving the EHRs using BC in the healthcare system were determined. Fourth, it analyzed and provided a detailed view of using s