Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP

AMP‐activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine β‐synthase) domains in the regulatory γ subunit. The structure of a CBS‐domain pair from human AMPK γ1 in complex with the physiological activator AMP and the pharmaco...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2007-05, Vol.63 (5), p.587-596
Hauptverfasser:	Day, Philip, Sharff, Andrew, Parra, Lina, Cleasby, Anne, Williams, Mark, Hörer, Stefan, Nar, Herbert, Redemann, Norbert, Tickle, Ian, Yon, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-activated kinase CBS domains
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Zusammenfassung:	AMP‐activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine β‐synthase) domains in the regulatory γ subunit. The structure of a CBS‐domain pair from human AMPK γ1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
ISSN:	1399-0047 0907-4449 1399-0047
DOI:	10.1107/S0907444907009110