inducible quinate-shikimate catabolic pathway in Neurospora crassa: Induction and regulation of enzyme synthesis

Department of Biology, Kline Biology Tower, Yale University, New Haven, Connecticut o652o, U.S.A. ABSTRACT Summary: The regulation of the synthesis of the first three enzymes of the quinate-shikimate catabolic pathway in Neurospora crassa has been studied. Induction of these enzymes is promoted efficiently by quinate and less so by 5-dehydroquinate and/or 5-dehydroshikimate. Shikimate has little or no inducing ability. The kinetics and steady-state rates of synthesis of the three catabolic enzymes have been examined. It is suggested that quinate-shikimate dehydrogenase, catabolic dehydro-quinase, and 5-dehydroshikimate dehydrase are regulated coordinately. Present address: Biology Department, Brookhaven National Laboratory, Upton, New York 11973, U.S.A.