Distribution of Phthiocerol Diester, Phenolic Mycosides and Related Compounds in Mycobacteria

Centre de Recherche de Biochimie et Génétique Cellulaires du CNRS, 118 route de Narbonne, 31062 Toulouse Cedex, France ABSTRACT Summary: Among 28 mycobacterial species studied, only Mycobacterium tuberculosis, M. bovis, M. africanum, M. marinum, M. kansasii, M. gastri and M. ulcerans produced waxes yielding long-chain β-diol components (called phthiocerol and companions) and polymethyl-branched fatty acids on saponification. The same mycobacterial species also produced diesters of phenol phthiocerol and companions. Fatty acids esterifying these fatty alcohols in M. marinum and M. ulcerans were found to belong to the phthioceranic series (dextrorotatory fatty acids), in contrast to those of the other species (laevorotatory fatty acids called mycocerosic acids), both groups having the same chain length and methyl-branched positions. M. kansasii and M. gastri contained the same waxes with identical structures, as did M. tuberculosis, M. bovis and M. africanum. Neither the type strain of M. tuberculosis , nor that of M. bovis or M. marinum accumulated the strain-specific phenolic glycolipids.