A Comparison of Phospholipase Activity, Cellular Adherence and Pathogenicity of Yeasts

ICI Pharmaceuticals Division, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK ABSTRACT Phospholipase A and lysophospholipase activities were measured in the culture fluid and in the blastospores of Candida albicans . When phospholipase activity was measured in six yeasts (four strains of C. albicans and a single strain each of Candida parapsilosis and Saccharomyces cerevisiae ) a correlation was found between this activity and two potential parameters of pathogenicity. The C. albicans isolates which adhered most strongly to buccal epithelial cells and were most pathogenic in mice had the highest phospholipase activities. Non-pathogenic yeasts, including C. albicans isolates which did not adhere and did not kill mice, had lower phospholipase activities.