Controlling biological networks by time-delayed signals

Controlling biological networks by time-delayed signals

This paper describes the use of time-delayed feedback to regulate the behaviour of biological networks. The general ideas on specific transcriptional regulatory and neural networks are demonstrated. It is shown that robust yet tunable controllers can be constructed that provide the biological system...

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Veröffentlicht in:Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences physical, and engineering sciences, 2010-01, Vol.368 (1911), p.439-454
Hauptverfasser: Orosz, Gábor, Moehlis, Jeff, Murray, Richard M.
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Bioengineering
Control
Delay circuits
Differential equations
Dynamical systems
Eigenvalues
Feedback, Physiological
Gene Regulatory Network
Gene Regulatory Networks
Genes
Genetic equilibrium
Messenger RNA
Neural Network
Neural Networks (Computer)
Neurons
Oscillators
Propagation delay
Signal Transduction
Systems Biology
Time Delay
Time Factors
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Beschreibung
Zusammenfassung:This paper describes the use of time-delayed feedback to regulate the behaviour of biological networks. The general ideas on specific transcriptional regulatory and neural networks are demonstrated. It is shown that robust yet tunable controllers can be constructed that provide the biological systems with model-engineered inputs. The results indicate that time delay modulation may serve as an efficient biocompatible control tool.
ISSN:1364-503X
1471-2962
DOI:10.1098/rsta.2009.0242