Simulation of molecular steps in muscle force generation

Simulation of molecular steps in muscle force generation

A previously described matrix method was adapted for solving the kinetics of reaction schemes. The method was used for simulation of the kinetics of a simplified acto-myosin ATPase cycle in muscle fibres: the simulated tension (= force) transients for pressure and temperature perturbations possess t...

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Veröffentlicht in:Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1999-07, Vol.266 (1427), p.1471-1475
Hauptverfasser: Gutfreund, H., Ranatunga, K. W.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine triphosphatases
Eigenvalues
Jumping
Kinetics
Mathematical constants
Matrices
Matrix Method
Muscle fibers
Muscle Force Generation
Numerical integration
Phosphates
Q-Matrix
Spectral theory
Temperature Jump
Tension Transients
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Beschreibung
Zusammenfassung:A previously described matrix method was adapted for solving the kinetics of reaction schemes. The method was used for simulation of the kinetics of a simplified acto-myosin ATPase cycle in muscle fibres: the simulated tension (= force) transients for pressure and temperature perturbations possess the basic features observed in the actual experimental records.
ISSN:0962-8452
1471-2954
DOI:10.1098/rspb.1999.0802