Prognosis Associated With CA19-9 Response Dynamics and Normalization During Neoadjuvant Therapy in Resected Pancreatic Adenocarcinoma

Prognosis Associated With CA19-9 Response Dynamics and Normalization During Neoadjuvant Therapy in Resected Pancreatic Adenocarcinoma

To characterize associations between carbohydrate antigen 19-9 (CA19-9) dynamics during neoadjuvant therapy (NT) and survival for patients with pancreatic ductal adenocarcinoma (PDAC). Although normalization of CA19-9 during NT is associated with improved outcomes following PDAC resection, we hypoth...

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Veröffentlicht in:Annals of surgery 2023-03, Vol.277 (3), p.484-490
Hauptverfasser: Newhook, Timothy E., Vreeland, Timothy J., Griffin, James F., Tidwell, Rebecca S. S., Prakash, Laura R., Koay, Eugene J., Ludmir, Ethan B., Smaglo, Brandon G., Pant, Shubham, Overman, Michael, Wolff, Robert A., Ikoma, Naruhiko, Maxwell, Jessica, Kim, Michael P., Lee, Jeffrey E., Katz, Matthew H. G., Tzeng, Ching-Wei D.
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - surgery
CA-19-9 Antigen
Carcinoma, Pancreatic Ductal - surgery
Humans
Neoadjuvant Therapy
Pancreatic Neoplasms - surgery
Prognosis
Retrospective Studies
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Zusammenfassung:To characterize associations between carbohydrate antigen 19-9 (CA19-9) dynamics during neoadjuvant therapy (NT) and survival for patients with pancreatic ductal adenocarcinoma (PDAC). Although normalization of CA19-9 during NT is associated with improved outcomes following PDAC resection, we hypothesize that CA19-9 dynamics during NT can improve prognostication. Characteristics for patients with PDAC undergoing NT (July 2011-October 2018) with ≥3 CA19-9 results (bilirubin
ISSN:0003-4932
1528-1140
DOI:10.1097/SLA.0000000000005184