Evaluation of the Microbotox Technique: An Algorithmic Approach for Lower Face and Neck Rejuvenation and a Crossover Clinical Trial

BACKGROUND:Microbotox consists of the injection of microdroplets of botulinum toxin into the dermis to improve the different lower-face and neck aging components. No clinical trial has evaluated its effect on the different face and neck components and no study has compared it to the “Nefertiti Lift” procedure. METHODS:In this crossover study, patients previously treated with the “Nefertiti Lift” were injected using the Microbotox technique. Using standardized pre-injection and post-injection photographs, the jowls, marionette lines, oral commissures, neck volume, and platysmal bands at maximal contraction and at rest were assessed with validated photonumeric scales. In addition, the overall appearance of the lower face and neck was evaluated by the Investigators and Subjects Global Aesthetic Improvement Score. Pain and patient satisfaction rates were also evaluated. RESULTS:Twenty-five out of the 30 patients previously treated with the Nefertiti technique were injected with a mean dose of 154 U using the Microbotox technique. Platysmal bands with contraction, jowls and neck volume reached a statistically significant improvement. The Microbotox technique improved the jowls and the neck volume more than the Nefertiti technique whereas the platysmal bands at rest and with contraction were more improved by the Nefertiti technique. 100 percent of patients were satisfied with both techniques and rated themselves as improved. CONCLUSIONS:The Microbotox technique is a useful, simple and safe procedure for the lower face and neck rejuvenation. It is mainly effective in treating neck and lower face soft tissue ptosis in contrast to the Nefertiti technique that is more effective on platysmal bands.