Intrathecal methotrexate-induced acute chorea

Intrathecal methotrexate is the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia. We describe a patient who developed acute chorea after last dose of intrathecal methotrexate therapy and recovered completely.

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Veröffentlicht in:	Journal of pediatric hematology/oncology 2009-01, Vol.31 (1), p.57-58
Hauptverfasser:	Necioğlu Orken, Dilek, Yldrmak, Yldz, Kenangil, Gülay, Kandraloğlu, Nursu, Forta, Hulki, Celik, Münevver
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Child Chorea - chemically induced Chorea - drug therapy Female Humans Injections, Spinal Methotrexate - administration & dosage Methotrexate - adverse effects Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Treatment Outcome
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Beschreibung
Zusammenfassung:	Intrathecal methotrexate is the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia. We describe a patient who developed acute chorea after last dose of intrathecal methotrexate therapy and recovered completely.
ISSN:	1077-4114 1536-3678
DOI:	10.1097/MPH.0b013e318190d434