Subclinic atherosclerosis and cardiovascular risk factors in HIV-infected children: PERI study

OBJECTIVESTo compare carotid intima-media thickness (cIMT) of children and adolescents with and without HIV infection and to determine associations among independent socio-demographic, clinical or cardiovascular variables and cIMT in HIV-infected children and adolescents. PATIENTS AND METHODSThis is...

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Veröffentlicht in:	Coronary artery disease 2008-05, Vol.19 (3), p.167-172
Hauptverfasser:	Giuliano, Isabela de C. B, de Freitas, Sergio F. T, de Souza, Maria, Caramelli, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent C-Reactive Protein - analysis Carotid Artery Diseases - complications Carotid Artery Diseases - pathology Case-Control Studies CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Child Female HIV Infections - complications Humans Male Reverse Transcriptase Inhibitors - adverse effects Stavudine - adverse effects Tunica Intima - pathology Tunica Media - pathology
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Zusammenfassung:	OBJECTIVESTo compare carotid intima-media thickness (cIMT) of children and adolescents with and without HIV infection and to determine associations among independent socio-demographic, clinical or cardiovascular variables and cIMT in HIV-infected children and adolescents. PATIENTS AND METHODSThis is a matched case–control study comparing 83 HIV-infected and 83 healthy children and adolescents. Clinical and laboratorial parameters, cIMT and echocardiogram were measured. RESULTSThe cIMT was higher in HIV-infected individuals (median 480 μm; interquartile range 463–518 μm) compared with controls (426 μm; range 415–453 μm, P
ISSN:	0954-6928 1473-5830
DOI:	10.1097/MCA.0b013e3282f6dffb