TWIN PRETERM NEONATES WITH CARDIAC TOXICITY RELATED TO LOPINAVIR/RITONAVIR THERAPY

We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other t...

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Veröffentlicht in:	The Pediatric infectious disease journal 2009-12, Vol.28 (12), p.1127-1129
Hauptverfasser:	MCARTHUR, Monica A, KALU, Stella U, FOULKS, Arlen R, ALY, Ashraf M, JAIN, Sunil K, PATEL, Janak A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Diseases in Twins - chemically induced Diseases of mother, fetus and pregnancy Electrocardiography Female Gynecology. Andrology. Obstetrics Heart - drug effects Heart Block Heart Diseases - chemically induced HIV Protease Inhibitors - adverse effects HIV Protease Inhibitors - therapeutic use Human viral diseases Humans Infant, Newborn Infant, Premature Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Lopinavir Medical sciences Pharmacology. Drug treatments Pregnancy. Fetus. Placenta Pyrimidinones - adverse effects Pyrimidinones - therapeutic use Ritonavir - adverse effects Ritonavir - therapeutic use Twins Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	We report twin neonates who were born prematurely at 32 weeks of gestation to a mother with human immunodeficiency virus infection. One of the twins developed complete heart block and dilated cardiomyopathy related to lopinavir/ritonavir therapy, a boosted protease-inhibitor agent, while the other twin developed mild bradycardia. We recommend caution in the use of lopinavir/ritonavir in the immediate neonatal period.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e3181acd17e