INCREASED β-2 MICROGLOBULINURIA IN HUMAN IMMUNODEFICIENCY VIRUS-1-INFECTED CHILDREN AND ADOLESCENTS TREATED WITH TENOFOVIR

A single-center cross sectional evaluation of β-2 microglobinuria as a marker of proximal renal tubule damage in 92 HIV-infected children showed that tenofovir treatment was significantly associated with very high abnormal values. In view of the very long duration of treatments for HIV infection, th...

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Veröffentlicht in:	The Pediatric infectious disease journal 2007-10, Vol.26 (10), p.949-951
Hauptverfasser:	Papaleo, Andrea, Warszawski, Josiane, Salomon, Rémi, Jullien, Vincent, Veber, Florence, Dechaux, Michèle, Blanche, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - adverse effects Adenine - analogs & derivatives Adolescent Adult beta 2-Microglobulin - analysis Biological and medical sciences Child Child, Preschool Cross-Sectional Studies Female HIV Infections - complications HIV Infections - drug therapy Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Organophosphonates - adverse effects Proteinuria Reverse Transcriptase Inhibitors - adverse effects Tenofovir Tubulopathies Urine - chemistry Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Zusammenfassung:	A single-center cross sectional evaluation of β-2 microglobinuria as a marker of proximal renal tubule damage in 92 HIV-infected children showed that tenofovir treatment was significantly associated with very high abnormal values. In view of the very long duration of treatments for HIV infection, their possible consequences for the childʼs growing body should be carefully evaluated.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/INF.0b013e3181256570