Management of Spasticity in Cerebral Palsy with Botulinum-A Toxin: Report of a Preliminary, Randomized, Double-Blind Trial

In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale...

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Veröffentlicht in:	Journal of pediatric orthopaedics 1994-05, Vol.14 (3), p.299-303
Hauptverfasser:	Koman, L Andrew, Mooney, James F, Smith, Beth P, Goodman, Amy, Mulvaney, Theresa
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Botulinum Toxins - administration & dosage Botulinum Toxins - therapeutic use Cerebral Palsy - complications Cerebral Palsy - drug therapy Child Child, Preschool Double-Blind Method Foot Deformities, Acquired - drug therapy Foot Deformities, Acquired - etiology Gait Humans Injections, Intramuscular Medical sciences Muscle Muscle Spasticity - drug therapy Pharmacology. Drug treatments Range of Motion, Articular
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Beschreibung
Zusammenfassung:	In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.
ISSN:	0271-6798 1539-2570
DOI:	10.1097/01241398-199405000-00005