Endomysial antibody production is not related to histological damage after in vitro gluten challenge

OBJECTIVETo determine whether in vitro induction of endomysial antibodies is an in vitro marker of coeliac toxicity. DESIGNTo determine whether in vitro endomysial antibodies induced by gliadin incubation correlate with histological damage induced by in vitro gliadin challenge. METHODS RESULTS CONCL...

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Veröffentlicht in:	European journal of gastroenterology & hepatology 2000-01, Vol.12 (1), p.57-60
Hauptverfasser:	Biagi, Federico, Parnell, Nick D. J, Ellis, Julia H, Ciclitira, Paul J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Autoantibodies - biosynthesis Autoantibodies - blood Biological and medical sciences Biomarkers - blood Celiac Disease - diagnosis Celiac Disease - immunology Celiac Disease - pathology Duodenum - immunology Duodenum - pathology Female Fluorescent Antibody Technique, Indirect Gastroenterology. Liver. Pancreas. Abdomen Gliadin - immunology Gliadin - toxicity Humans Male Medical sciences Middle Aged Muscle, Smooth - immunology Organ Culture Techniques Other diseases. Semiology Predictive Value of Tests Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Zusammenfassung:	OBJECTIVETo determine whether in vitro induction of endomysial antibodies is an in vitro marker of coeliac toxicity. DESIGNTo determine whether in vitro endomysial antibodies induced by gliadin incubation correlate with histological damage induced by in vitro gliadin challenge. METHODS RESULTS CONCLUSIONSIn vitro, endomysial antibody induction cannot be used as a marker of coeliac toxicity. Endomysial antibodies are not necessary for generating the histological lesion of coeliac disease. Eur J Gastroenterol Hepatol 12:57 - 60 © 2000 Lippincott Williams & WilkinsEuropean Journal of Gastroenterology & Hepatology 2000, 12:57-60
ISSN:	0954-691X 1473-5687
DOI:	10.1097/00042737-200012010-00011