Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: A case report

This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenyto...

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Veröffentlicht in:	Therapeutic drug monitoring 2003-02, Vol.25 (1), p.117-119
Hauptverfasser:	FRIDELL, Jonathan A, JAIN, Ashok Kumar B, PATEL, Kusum, MOHAMED VIRJI, T, RAO, K. N, FUNG, John J, VENKATARAMANAN, Raman
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Biological and medical sciences Drug Interactions Female Graft Rejection - blood Graft Rejection - drug therapy Humans Liver Transplantation - statistics & numerical data Medical sciences Middle Aged Miscellaneous Pharmacology. Drug treatments Phenytoin - pharmacokinetics Phenytoin - therapeutic use Sirolimus - blood Sirolimus - therapeutic use
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Zusammenfassung:	This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.
ISSN:	0163-4356 1536-3694
DOI:	10.1097/00007691-200302000-00019