Development of a quantitative vancomycin immunoassay for the abbott AxSYM analyzer

A novel fluorescence polarization immunoassay for vancomycin on Abbott AxSYM analyzer is described. The immunoassay allows for the accurate quantification of vancomycin in the presence of the crystalline degradation product (CDP). It displays dilution linearity from 1.0 microg/ml to 100.0 microg/ml,...

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Veröffentlicht in:	Therapeutic drug monitoring 1998-04, Vol.20 (2), p.191-201
Hauptverfasser:	ADAMCZYK, M, BRATE, E. M, CHIAPPETTA, E. G, GINSBURG, S, HOFFMAN, E, KLEIN, C, PERKOWITZ, M. M, REGE, S. D, CHOU, P. P, COSTANTINO, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Anti-Bacterial Agents - blood Anti-Bacterial Agents - chemistry Biological and medical sciences Calibration Chromatography, High Pressure Liquid Confidence Intervals Crystallization Drug Contamination - prevention & control Drug Interactions Drug Monitoring - instrumentation Drug Monitoring - methods Female Fluorescence Polarization Immunoassay - instrumentation Fluorescence Polarization Immunoassay - methods General pharmacology Humans Linear Models Medical sciences Mice Nonprescription Drugs - chemistry Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Spectrophotometry, Ultraviolet Vancomycin - blood Vancomycin - chemistry
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Zusammenfassung:	A novel fluorescence polarization immunoassay for vancomycin on Abbott AxSYM analyzer is described. The immunoassay allows for the accurate quantification of vancomycin in the presence of the crystalline degradation product (CDP). It displays dilution linearity from 1.0 microg/ml to 100.0 microg/ml, coefficients of variation ranging from 2.94% to 4.26%, recovery from 98% to 105%, and a sensitivity of
ISSN:	0163-4356 1536-3694
DOI:	10.1097/00007691-199804000-00010