Effect of ofloxacin on the pharmacokinetics of a single intravenous theophylline dose

The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immu...

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Veröffentlicht in:Therapeutic drug monitoring 1988-01, Vol.10 (2), p.160-163
Hauptverfasser: AL-TURK, W. A, SHAHEEN, O. M, SADEQ OTHMAN, KHALAF, R. M, AWIDI, A. S
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Sprache:eng
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Zusammenfassung:The effect of ofloxacin taken for 8 days (200 mg twice daily) on the pharmacokinetics of a single intravenous dose of theophylline (4.3 mg/kg over 15 min) was studied in a crossover procedure among seven healthy male volunteers. Theophylline concentrations were measured serially for 10 h by the immunofluorescence polarization technique. No significant effect of ofloxacin was found on theophylline clearance, half-life, or volume of distribution. It is therefore concluded that ofloxacin and theophylline can be safely administered together.
ISSN:0163-4356
1536-3694
DOI:10.1097/00007691-198802000-00007