Impact of cefaclor on the pharmacokinetics of theophylline

The influence of cefaclor taken for 8 days (250 mg every 8 h) on the pharmacokinetics of a single intravenous dose of theophylline (2 mg/kg administered on the 8th cefaclor day) was studied in a crossover fashion among 11 healthy adults (10 men and one woman). Theophylline concentrations were measur...

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Veröffentlicht in:	Therapeutic drug monitoring 1986-01, Vol.8 (2), p.151-154
Hauptverfasser:	BACHMANN, K, SCHWARTZ, J, FORNEY, R. B. JR, JAUREGUI, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Cefaclor - adverse effects Cefaclor - pharmacology Cephalexin - analogs & derivatives Drug Interactions Female Half-Life Humans Kinetics Male Medical sciences Pharmacology. Drug treatments Respiratory system Theophylline - adverse effects Theophylline - metabolism
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Beschreibung
Zusammenfassung:	The influence of cefaclor taken for 8 days (250 mg every 8 h) on the pharmacokinetics of a single intravenous dose of theophylline (2 mg/kg administered on the 8th cefaclor day) was studied in a crossover fashion among 11 healthy adults (10 men and one woman). Theophylline concentrations were measured serially for 12 h by an immunofluorescence polarization technique. No influence of cefaclor was detectable on theophylline clearance, half-life, or volume of distribution. It is concluded that cefaclor and theophylline can be administered together safely.
ISSN:	0163-4356 1536-3694
DOI:	10.1097/00007691-198606000-00004