Edematous pancreatitis associated with intravenous pentamidine

A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreati...

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Veröffentlicht in:	Southern medical journal (Birmingham, Ala.) Ala.), 1991-06, Vol.84 (6), p.796-798
Hauptverfasser:	Villamil, A, Hammer, R A, Rodriguez, F H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - physiopathology Adult Fat Necrosis - complications Fat Necrosis - pathology Humans Liver Function Tests Male Pancreatitis - chemically induced Pancreatitis - complications Pancreatitis - mortality Pentamidine - adverse effects Pneumonia, Pneumocystis - complications Pneumonia, Pneumocystis - drug therapy Risk Factors
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Zusammenfassung:	A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreatitis should be emphasized. With current clinical trials testing other routes of administration, fatal complications associated with IV pentamidine therapy will be minimized.
ISSN:	0038-4348
DOI:	10.1097/00007611-199106000-00034