Fatal pulmonary fibrosis from low-dose bleomycin therapy

Six weeks after receiving a total dose of 20 units of bleomycin sulfate as part of BACOP therapy for non-Hodgkin's lymphoma, our patient had dyspnea and cough with marked hypoxemia. Open lung biopsy established the diagnosis of "bleomycin lung," confirmed by postmortem examination. Fa...

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Veröffentlicht in:	Southern medical journal (Birmingham, Ala.) Ala.), 1987-05, Vol.80 (5), p.646-649
Hauptverfasser:	Bechard, D E, Fairman, R P, DeBlois, G G, Via, C T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Bleomycin - administration & dosage Bleomycin - adverse effects Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Doxorubicin - administration & dosage Doxorubicin - adverse effects Humans Lymphoma, Non-Hodgkin - drug therapy Male Prednisone - administration & dosage Prednisone - adverse effects Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Vincristine - administration & dosage Vincristine - adverse effects
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Beschreibung
Zusammenfassung:	Six weeks after receiving a total dose of 20 units of bleomycin sulfate as part of BACOP therapy for non-Hodgkin's lymphoma, our patient had dyspnea and cough with marked hypoxemia. Open lung biopsy established the diagnosis of "bleomycin lung," confirmed by postmortem examination. Fatal bleomycin pulmonary toxicity can develop with any dosage, and routine tests are incapable of detecting early, reversible toxicity.
ISSN:	0038-4348
DOI:	10.1097/00007611-198705000-00024