SUCCESSFUL TREATMENT OF VISCERAL LEISHMANIASIS WITH ALLOPURINOL PLUS KETOCONAZOLE IN AN INFANT WHO DEVELOPED PANCREATITIS CAUSED BY MEGLUMINE ANTIMONIATE

SUCCESSFUL TREATMENT OF VISCERAL LEISHMANIASIS WITH ALLOPURINOL PLUS KETOCONAZOLE IN AN INFANT WHO DEVELOPED PANCREATITIS CAUSED BY MEGLUMINE ANTIMONIATE

Pentavalent antimony is still the drug of choice in the treatment of visceral leishmaniasis. Pantavalent antimony can cause a wide range of adverse effects, the most serious of which are cardiotoxicity and hepatotoxicity. Acute pancreatitis is a rarely reported adverse effect. An infant who develope...

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Veröffentlicht in:The Pediatric infectious disease journal 2001-04, Vol.20 (4), p.455-457
Hauptverfasser: Kuyucu, Necdet, Kara, Cengiz, Bakirtaç, Arzu, Teziç, Tahsin
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Allopurinol - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiprotozoal Agents - adverse effects
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Child, Preschool
Drug toxicity and drugs side effects treatment
Humans
Ketoconazole - therapeutic use
Leishmaniasis, Visceral - drug therapy
Male
Medical sciences
Meglumine - adverse effects
Meglumine - therapeutic use
Meglumine Antimoniate
Organometallic Compounds - adverse effects
Organometallic Compounds - therapeutic use
Pancreatitis - chemically induced
Pharmacology. Drug treatments
Toxicity: digestive system
Tropical medicine
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Zusammenfassung:Pentavalent antimony is still the drug of choice in the treatment of visceral leishmaniasis. Pantavalent antimony can cause a wide range of adverse effects, the most serious of which are cardiotoxicity and hepatotoxicity. Acute pancreatitis is a rarely reported adverse effect. An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.
ISSN:0891-3668
1532-0987
DOI:10.1097/00006454-200104000-00021