Effect of Hyperbaric Oxygenation on Existing Oral Mucosal Carcinoma

Hyperbaric oxygen therapy (HBO) is used to treat some complications of head and neck carcinoma treatment. Several patients treated with HBO have had rapid growth of a clinically cured squamous cell carcinoma. Prior studies have produced conflicting evidence about the effect of HBO on tumor growth. T...

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Veröffentlicht in:	The Laryngoscope 1996-08, Vol.106 (8), p.957-959
Hauptverfasser:	McDonald, Kathleen R., Bradfield, Joseph J., Kinsella, John K., Kumar, Druv, Mader, Jon A., Hokanson, James A., Calhoun, Karen H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cheek Cricetinae Evaluation Studies as Topic Hyperbaric Oxygenation Medical sciences Mesocricetus Mouth Mucosa Mouth Neoplasms - pathology Mouth Neoplasms - therapy Neoplasm Metastasis Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Time Factors Tumors
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Zusammenfassung:	Hyperbaric oxygen therapy (HBO) is used to treat some complications of head and neck carcinoma treatment. Several patients treated with HBO have had rapid growth of a clinically cured squamous cell carcinoma. Prior studies have produced conflicting evidence about the effect of HBO on tumor growth. This study was undertaken to determine the effects of HBO on established squamous cell carcinoma. Forty Golden Syrian hamster cheek‐pouch carcinomas were induced with the established chemical carcinogen 9,10‐dimethyl‐1,2‐benzanthracene. Twenty hamsters underwent 30 HBO dives for 60 minutes each to 2.81 atm, while 20 served as controls. At necropsy, animals receiving HBO therapy had significantly smaller tumors (P
ISSN:	0023-852X 1531-4995
DOI:	10.1097/00005537-199608000-00008