Lisinopril Combined with Atenolol in the Treatment of Hypertension

This is a double-blind, randomized parallel-group, multicenter study comprising 340 hypertensive patients. All were treated with 50 mg of atenolol once daily. If their recumbent diastolic blood pressure was ≥95 and ≤ 115 mm Hg after a 4-week open run-in period, patients were randomized to receive additionally. 5, 10, or 20 mg of lisinopril once daily or placebo for a further 8-week period in a double-blind fashion. The additional effects on the trough (24–28 h after tablet intake) diastolic blood pressure of placebo and 5 mg of lisinopril were not statistically significant. Lisinopril at 10 and 20 mg reduced the recumbent diastolic blood pressure by 3.2 and 3.3 mm Hg, respectively, more than placebo (p = 0.010–0.011). The recumbent systolic blood pressure and heart rate did not change. The side effect profile of lisinopril was not different from that of placebo and adverse effects were few and mild.