Effects of Endothelin-1 and Endothelin-3 on Blood Pressure in Conscious Hypertensive Rats

SUMMARYThe vasopressor potencies of endothelin (ET) in SHR, DOC, and CLIP hypertensive rats were determined. Rat endothelin (ET-3) showed greater vasopressor activity in SHR. The mechanism of this greater potency and the pathogenesis of hypertension in SHR remains to be investigated.

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1989, Vol.13 Suppl 5, p.S207-208
Hauptverfasser:	Watanabe, Takushi X, Kumagaye, Shin-Ichiroh, Nishio, Hideki, Nakajima, Kiichiro, Kimura, Terutoshi, Sakakibara, Shumpei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Desoxycorticosterone Endothelins Heart Rate - drug effects Hypertension - chemically induced Hypertension - physiopathology Hypertension, Renal - drug therapy Peptides - pharmacology Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY
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Zusammenfassung:	SUMMARYThe vasopressor potencies of endothelin (ET) in SHR, DOC, and CLIP hypertensive rats were determined. Rat endothelin (ET-3) showed greater vasopressor activity in SHR. The mechanism of this greater potency and the pathogenesis of hypertension in SHR remains to be investigated.
ISSN:	0160-2446 1533-4023
DOI:	10.1097/00005344-198900135-00059