Vascular endothelium, mechanical properties of the arterial wall and local angiotensin converting enzyme inhibition

METHODS:An experimental model of in situ isolated carotid arteries was used to study the contribution made by angiotensin II (Ang II) towards the mechanical properties of the arterial wall in 12-week-old Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. The effects of local incubation wi...

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Veröffentlicht in:	Journal of hypertension 1992-07, Vol.10 Suppl 5 (5), p.S21-S27
Hauptverfasser:	Levy, Bernard I, Stefas, Lambros, Babalis, Dimitris, Benetos, Athanase
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - physiology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Carotid Arteries - drug effects Carotid Arteries - physiology Compliance - drug effects Dipeptides - pharmacology Endothelium, Vascular - physiology In Vitro Techniques Lisinopril Male Potassium Cyanide - pharmacology Random Allocation Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Angiotensin - drug effects Saralasin - pharmacology
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Zusammenfassung:	METHODS:An experimental model of in situ isolated carotid arteries was used to study the contribution made by angiotensin II (Ang II) towards the mechanical properties of the arterial wall in 12-week-old Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. The effects of local incubation with saralasin (Sar-Thr-Ang II, 10mol/l) and with lisinopril (5 x 10mol/l) on carotid compliance were compared to the effects of removing the endothelium and the effects of totally abolishing vasomotor tone with potassium cyanide (0.1 mg/ml). RESULTS:With an intact endothelium, local incubation with lisinopril increased carotid compliance by 23% in WKY rats (P
ISSN:	0263-6352 0952-1178 1473-5598
DOI:	10.1097/00004872-199207005-00004