Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency

A double-blind, randomized, placebo-controlled, parallel group study was performed in 80 adult outpatients meeting ICD-10 criteria for major depression and with a Montgomery -Asberg Depression Rating Scale (MADRS) score of at least 18 at baseline. All patients received paroxetine (20 mg once a day)...

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Veröffentlicht in:International clinical psychopharmacology 1997-03, Vol.12 (2), p.81-90
Hauptverfasser: Tome, M B, Isaac, M T, Harte, R, Holland, C
Format: Artikel
Sprache:eng
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Zusammenfassung:A double-blind, randomized, placebo-controlled, parallel group study was performed in 80 adult outpatients meeting ICD-10 criteria for major depression and with a Montgomery -Asberg Depression Rating Scale (MADRS) score of at least 18 at baseline. All patients received paroxetine (20 mg once a day) plus either pindolol (2.5 mg three times a day) or matching placebo for 6 weeks. Analysis of the day 14 MADRS scores on an intent-to-treat basis revealed a treatment-by-centre interaction, with a significant effect of pindolol being demonstrable at only one centre. At this centre. 25% of the paroxetine plus pindolol group and 0% of the paroxetine phis placebo group showed a decrease of at least 50% from baseline MADRS by day 4 (p < 0.05). At day 14, the proportions were 73% and 7%, respectively (p < 0.0011. Analysis of covariance on a “per-protocol” population demonstrated a significant accelerator effect of pindolol at days 4 and 7 in the a!)sence of a treatment by-centre interaction, but a centre effect was apparent at later time-points. The results suggest that the latency of antidepressant action can be reduced with pindolol augmentation. A large multicentre study is in progress to investigate this effect further.
ISSN:0268-1315
1473-5857
DOI:10.1097/00004850-199703000-00003