Wasopressin-Related Bullous Disease of the Legs

We report a 33-year-old man who developed cutaneous lecrosis of the lower extremities with extensive bulla formation after i.v. administration of vasopressin for the reatment of bleeding esophageal varices. Due to its lotent nonselective vasoconstrictive action, vasopressin lot only may induce cardiac and gastrointestinal ischenia, but cutaneous ischemia as well. As in our patient, this may lead to extensive necrotic skin lesions at sites listant from the infusion.