Sclerosing Cholangitis from Intraarterial Floxuridine

The development of biliary strictures simulating sclerosing cholangitis is now well-known. We report a patient undergoing intraarterial chemotherapy for metastatic colon cancer of the liver in whom segmental intrahepatic biliary strictures occurred remote from known metastases. The patient remains a...

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Veröffentlicht in:	Journal of clinical gastroenterology 1986-12, Vol.8 (6), p.690-693
Hauptverfasser:	Dikengil, Asim, Siskind, Barry N, Morse, Steven S, Swedlund, Anne, Bober-Sorcinelli, Kathleen E, Burrell, Morton I, Margulis, Alexander R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Aged Bile Ducts - pathology Biological and medical sciences Cholestasis, Intrahepatic - chemically induced Cholestasis, Intrahepatic - diagnostic imaging Drug toxicity and drugs side effects treatment Female Floxuridine - adverse effects Floxuridine - therapeutic use Hepatic Artery Humans Infusions, Intra-Arterial - adverse effects Liver Cirrhosis, Biliary - chemically induced Liver Neoplasms - drug therapy Liver Neoplasms - secondary Medical sciences Pharmacology. Drug treatments Sclerosis Sigmoid Neoplasms - surgery Tomography, X-Ray Computed Toxicity: cardiovascular system
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Zusammenfassung:	The development of biliary strictures simulating sclerosing cholangitis is now well-known. We report a patient undergoing intraarterial chemotherapy for metastatic colon cancer of the liver in whom segmental intrahepatic biliary strictures occurred remote from known metastases. The patient remains alive 3–4 years after documented liver metastases with severe progressive portal hypertension, hypersplenism, and fat malabsorption. A table of cases so far reported is given.
ISSN:	0192-0790 1539-2031
DOI:	10.1097/00004836-198612000-00022