Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction
We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical gastroenterology 1981-09, Vol.3 (3), p.271-279 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 279 |
|---|---|
| container_issue | 3 |
| container_start_page | 271 |
| container_title | Journal of clinical gastroenterology |
| container_volume | 3 |
| creator | Dickinson, Douglas S Bailey, William C Hirschowitz, Basil I Soong, Seng-Jaw Eidus, Leslie Hodgkin, Mary M |
| description | We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction, mostly hepatocellular, three having overt hepatitis. When 12 other patients who drank alcohol were excluded from analysis, there were still 15/89 with significant liver dysfunction, 12 of whom were slow acetylators (p |
| doi_str_mv | 10.1097/00004836-198109000-00012 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1097_00004836_198109000_00012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>7288121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3552-6564da7a2bf69eca5fa32fabf14bfdb63aba0668279ce082e3b283d031bda0273</originalsourceid><addsrcrecordid>eNp1kF1LwzAUhoMoc05_gpBLvYjmo21S72Q6VxgKotchaRJW17UjaR3z1xvt3J0HDofz8R54HwAgwTcE5_wWx0gEyxDJRRzEDsUk9AiMScpyRDEjx2CMSU4R5jk-BWchfMQLzhgZgRGnQhBKxuDutQorOFNl1_oAXethEdqmUl-VgVfF8_waFY3pS2vgovq0Hj7sguubsqva5hycOFUHe7GvE_A-e3ybztHi5amY3i9QydKUoizNEqO4otpluS1V6hSjTmlHEu2MzpjSCmeZoDwvLRbUMk0FM9GANgpTziZADH9L34bgrZMbX62V30mC5Q8N-UdDHmjIXxpRejlIN71eW3MQ7u3HfTLst23dWR9Wdb-1Xi6tqrul_A8y-wZ_fGkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction</title><source>MEDLINE</source><source>Journals@Ovid Ovid Autoload</source><creator>Dickinson, Douglas S ; Bailey, William C ; Hirschowitz, Basil I ; Soong, Seng-Jaw ; Eidus, Leslie ; Hodgkin, Mary M</creator><creatorcontrib>Dickinson, Douglas S ; Bailey, William C ; Hirschowitz, Basil I ; Soong, Seng-Jaw ; Eidus, Leslie ; Hodgkin, Mary M</creatorcontrib><description>We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction, mostly hepatocellular, three having overt hepatitis. When 12 other patients who drank alcohol were excluded from analysis, there were still 15/89 with significant liver dysfunction, 12 of whom were slow acetylators (p<0.05). The only other risk factor was age. By combining acetylator phenotype with age, but excluding alcohol, we calculated the risk of INH-induced liver enzyme elevation as followsunder 35 years—fast acetylators, 3.7%, slow acetylators, 13%; over 35—fast acetylators, 13.2%, slow acetylators, 37% (p <0.02). Fast acetylation is thus not a risk factor for developing INH-induced liver dysfunction; indeed, the contrary seems to be the case.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-198109000-00012</identifier><identifier>PMID: 7288121</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Acetylation ; Age Factors ; Alcohol Drinking ; Chemical and Drug Induced Liver Injury - etiology ; Continental Population Groups ; Female ; Humans ; Isoniazid - adverse effects ; Isoniazid - metabolism ; Liver - metabolism ; Liver Function Tests ; Male ; Phenotype ; Prospective Studies ; Risk ; Time Factors</subject><ispartof>Journal of clinical gastroenterology, 1981-09, Vol.3 (3), p.271-279</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3552-6564da7a2bf69eca5fa32fabf14bfdb63aba0668279ce082e3b283d031bda0273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7288121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dickinson, Douglas S</creatorcontrib><creatorcontrib>Bailey, William C</creatorcontrib><creatorcontrib>Hirschowitz, Basil I</creatorcontrib><creatorcontrib>Soong, Seng-Jaw</creatorcontrib><creatorcontrib>Eidus, Leslie</creatorcontrib><creatorcontrib>Hodgkin, Mary M</creatorcontrib><title>Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction, mostly hepatocellular, three having overt hepatitis. When 12 other patients who drank alcohol were excluded from analysis, there were still 15/89 with significant liver dysfunction, 12 of whom were slow acetylators (p<0.05). The only other risk factor was age. By combining acetylator phenotype with age, but excluding alcohol, we calculated the risk of INH-induced liver enzyme elevation as followsunder 35 years—fast acetylators, 3.7%, slow acetylators, 13%; over 35—fast acetylators, 13.2%, slow acetylators, 37% (p <0.02). Fast acetylation is thus not a risk factor for developing INH-induced liver dysfunction; indeed, the contrary seems to be the case.</description><subject>Acetylation</subject><subject>Age Factors</subject><subject>Alcohol Drinking</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Continental Population Groups</subject><subject>Female</subject><subject>Humans</subject><subject>Isoniazid - adverse effects</subject><subject>Isoniazid - metabolism</subject><subject>Liver - metabolism</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Phenotype</subject><subject>Prospective Studies</subject><subject>Risk</subject><subject>Time Factors</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUhoMoc05_gpBLvYjmo21S72Q6VxgKotchaRJW17UjaR3z1xvt3J0HDofz8R54HwAgwTcE5_wWx0gEyxDJRRzEDsUk9AiMScpyRDEjx2CMSU4R5jk-BWchfMQLzhgZgRGnQhBKxuDutQorOFNl1_oAXethEdqmUl-VgVfF8_waFY3pS2vgovq0Hj7sguubsqva5hycOFUHe7GvE_A-e3ybztHi5amY3i9QydKUoizNEqO4otpluS1V6hSjTmlHEu2MzpjSCmeZoDwvLRbUMk0FM9GANgpTziZADH9L34bgrZMbX62V30mC5Q8N-UdDHmjIXxpRejlIN71eW3MQ7u3HfTLst23dWR9Wdb-1Xi6tqrul_A8y-wZ_fGkA</recordid><startdate>198109</startdate><enddate>198109</enddate><creator>Dickinson, Douglas S</creator><creator>Bailey, William C</creator><creator>Hirschowitz, Basil I</creator><creator>Soong, Seng-Jaw</creator><creator>Eidus, Leslie</creator><creator>Hodgkin, Mary M</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198109</creationdate><title>Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction</title><author>Dickinson, Douglas S ; Bailey, William C ; Hirschowitz, Basil I ; Soong, Seng-Jaw ; Eidus, Leslie ; Hodgkin, Mary M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-6564da7a2bf69eca5fa32fabf14bfdb63aba0668279ce082e3b283d031bda0273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Acetylation</topic><topic>Age Factors</topic><topic>Alcohol Drinking</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Continental Population Groups</topic><topic>Female</topic><topic>Humans</topic><topic>Isoniazid - adverse effects</topic><topic>Isoniazid - metabolism</topic><topic>Liver - metabolism</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Phenotype</topic><topic>Prospective Studies</topic><topic>Risk</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dickinson, Douglas S</creatorcontrib><creatorcontrib>Bailey, William C</creatorcontrib><creatorcontrib>Hirschowitz, Basil I</creatorcontrib><creatorcontrib>Soong, Seng-Jaw</creatorcontrib><creatorcontrib>Eidus, Leslie</creatorcontrib><creatorcontrib>Hodgkin, Mary M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dickinson, Douglas S</au><au>Bailey, William C</au><au>Hirschowitz, Basil I</au><au>Soong, Seng-Jaw</au><au>Eidus, Leslie</au><au>Hodgkin, Mary M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1981-09</date><risdate>1981</risdate><volume>3</volume><issue>3</issue><spage>271</spage><epage>279</epage><pages>271-279</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><abstract>We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction, mostly hepatocellular, three having overt hepatitis. When 12 other patients who drank alcohol were excluded from analysis, there were still 15/89 with significant liver dysfunction, 12 of whom were slow acetylators (p<0.05). The only other risk factor was age. By combining acetylator phenotype with age, but excluding alcohol, we calculated the risk of INH-induced liver enzyme elevation as followsunder 35 years—fast acetylators, 3.7%, slow acetylators, 13%; over 35—fast acetylators, 13.2%, slow acetylators, 37% (p <0.02). Fast acetylation is thus not a risk factor for developing INH-induced liver dysfunction; indeed, the contrary seems to be the case.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>7288121</pmid><doi>10.1097/00004836-198109000-00012</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1981-09, Vol.3 (3), p.271-279 |
| issn | 0192-0790 1539-2031 |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00004836_198109000_00012 |
| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Acetylation Age Factors Alcohol Drinking Chemical and Drug Induced Liver Injury - etiology Continental Population Groups Female Humans Isoniazid - adverse effects Isoniazid - metabolism Liver - metabolism Liver Function Tests Male Phenotype Prospective Studies Risk Time Factors |
| title | Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T19%3A41%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20Factors%20for%20Isoniazid%20(INH)-Induced%20Liver%20Dysfunction&rft.jtitle=Journal%20of%20clinical%20gastroenterology&rft.au=Dickinson,%20Douglas%20S&rft.date=1981-09&rft.volume=3&rft.issue=3&rft.spage=271&rft.epage=279&rft.pages=271-279&rft.issn=0192-0790&rft.eissn=1539-2031&rft_id=info:doi/10.1097/00004836-198109000-00012&rft_dat=%3Cpubmed_cross%3E7288121%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7288121&rfr_iscdi=true |