Risk Factors for Isoniazid (INH)-Induced Liver Dysfunction

We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction...

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Veröffentlicht in:	Journal of clinical gastroenterology 1981-09, Vol.3 (3), p.271-279
Hauptverfasser:	Dickinson, Douglas S, Bailey, William C, Hirschowitz, Basil I, Soong, Seng-Jaw, Eidus, Leslie, Hodgkin, Mary M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Age Factors Alcohol Drinking Chemical and Drug Induced Liver Injury - etiology Continental Population Groups Female Humans Isoniazid - adverse effects Isoniazid - metabolism Liver - metabolism Liver Function Tests Male Phenotype Prospective Studies Risk Time Factors
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Zusammenfassung:	We examined prospectively risk factors which might contribute to INH-induced liver damage in 113 patients taking preventive INH for at least 8 weeks. Twelve who had abnormal initial liver tests did not get worse with INH, while 19/101 with normal initial tests developed significant liver dysfunction, mostly hepatocellular, three having overt hepatitis. When 12 other patients who drank alcohol were excluded from analysis, there were still 15/89 with significant liver dysfunction, 12 of whom were slow acetylators (p
ISSN:	0192-0790 1539-2031
DOI:	10.1097/00004836-198109000-00012