Coadministration of fluvoxamine increases serum concentrations of haloperidol
Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients a...
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| Veröffentlicht in: | Journal of clinical psychopharmacology 1994-10, Vol.14 (5), p.340-343 |
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| container_end_page | 343 |
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| container_issue | 5 |
| container_start_page | 340 |
| container_title | Journal of clinical psychopharmacology |
| container_volume | 14 |
| creator | DANIEL, D. G RANDOLPH, C LINNOILA, M JASKIW, G HANDEL, S WILLIAMS, T ABI-DARGHAM, A SHOAF, S EGAN, M AHMED ELKASHEF LIBOFF, S |
| description | Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine. |
| doi_str_mv | 10.1097/00004714-199410000-00009 |
| format | Article |
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G ; RANDOLPH, C ; LINNOILA, M ; JASKIW, G ; HANDEL, S ; WILLIAMS, T ; ABI-DARGHAM, A ; SHOAF, S ; EGAN, M ; AHMED ELKASHEF ; LIBOFF, S</creator><creatorcontrib>DANIEL, D. G ; RANDOLPH, C ; LINNOILA, M ; JASKIW, G ; HANDEL, S ; WILLIAMS, T ; ABI-DARGHAM, A ; SHOAF, S ; EGAN, M ; AHMED ELKASHEF ; LIBOFF, S</creatorcontrib><description>Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.</description><identifier>ISSN: 0271-0749</identifier><identifier>EISSN: 1533-712X</identifier><identifier>DOI: 10.1097/00004714-199410000-00009</identifier><identifier>PMID: 7806690</identifier><identifier>CODEN: JCPYDR</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Benztropine - administration & dosage ; Benztropine - adverse effects ; Benztropine - pharmacokinetics ; Biological and medical sciences ; Chronic Disease ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Drug Therapy, Combination ; Drug toxicity and drugs side effects treatment ; Fluvoxamine - administration & dosage ; Fluvoxamine - adverse effects ; Fluvoxamine - pharmacokinetics ; Haloperidol - administration & dosage ; Haloperidol - adverse effects ; Haloperidol - pharmacokinetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Neurologic Examination - drug effects ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Schizophrenia - blood ; Schizophrenia - drug therapy ; Schizophrenic Psychology</subject><ispartof>Journal of clinical psychopharmacology, 1994-10, Vol.14 (5), p.340-343</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4255297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7806690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DANIEL, D. G</creatorcontrib><creatorcontrib>RANDOLPH, C</creatorcontrib><creatorcontrib>LINNOILA, M</creatorcontrib><creatorcontrib>JASKIW, G</creatorcontrib><creatorcontrib>HANDEL, S</creatorcontrib><creatorcontrib>WILLIAMS, T</creatorcontrib><creatorcontrib>ABI-DARGHAM, A</creatorcontrib><creatorcontrib>SHOAF, S</creatorcontrib><creatorcontrib>EGAN, M</creatorcontrib><creatorcontrib>AHMED ELKASHEF</creatorcontrib><creatorcontrib>LIBOFF, S</creatorcontrib><title>Coadministration of fluvoxamine increases serum concentrations of haloperidol</title><title>Journal of clinical psychopharmacology</title><addtitle>J Clin Psychopharmacol</addtitle><description>Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.</description><subject>Adult</subject><subject>Benztropine - administration & dosage</subject><subject>Benztropine - adverse effects</subject><subject>Benztropine - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Fluvoxamine - administration & dosage</subject><subject>Fluvoxamine - adverse effects</subject><subject>Fluvoxamine - pharmacokinetics</subject><subject>Haloperidol - administration & dosage</subject><subject>Haloperidol - adverse effects</subject><subject>Haloperidol - pharmacokinetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Neurologic Examination - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenic Psychology</subject><issn>0271-0749</issn><issn>1533-712X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9PwzAMxSMEGmPwEZB64Fqw02RpjmjinzTEBSRulZsmIqhtpqRD8O1ZWZkPtvz8ng8_xjKEawStbmBXQqHIUWuB45aPTR-xOcqiyBXy92M2B64wByX0KTtL6RMAheJyxmaqhOVSw5w9rwI1ne99GiINPvRZcJlrt1_hm3ayzXxvoqVkU5Zs3HaZCb2x_WROo_uD2rCx0TehPWcnjtpkL6a5YG_3d6-rx3z98vC0ul3nhpdiyEtpNDlZy6WqOaECWWgsG7CNBCyQhJHIXdMYLazAQlowRFAicq6hdrpYsHL_18SQUrSu2kTfUfypEKoRUPUPqDoA-pPG6OU-utnWnW0OwYnI7n413SkZal2k3vh0sAkuJdeq-AWP326T</recordid><startdate>19941001</startdate><enddate>19941001</enddate><creator>DANIEL, D. G</creator><creator>RANDOLPH, C</creator><creator>LINNOILA, M</creator><creator>JASKIW, G</creator><creator>HANDEL, S</creator><creator>WILLIAMS, T</creator><creator>ABI-DARGHAM, A</creator><creator>SHOAF, S</creator><creator>EGAN, M</creator><creator>AHMED ELKASHEF</creator><creator>LIBOFF, S</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19941001</creationdate><title>Coadministration of fluvoxamine increases serum concentrations of haloperidol</title><author>DANIEL, D. G ; RANDOLPH, C ; LINNOILA, M ; JASKIW, G ; HANDEL, S ; WILLIAMS, T ; ABI-DARGHAM, A ; SHOAF, S ; EGAN, M ; AHMED ELKASHEF ; LIBOFF, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-85c9af5b567b2a17053918d0ed50131a4c512fddc94e4135e0caa08112290bf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Benztropine - administration & dosage</topic><topic>Benztropine - adverse effects</topic><topic>Benztropine - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Cross-Over Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Fluvoxamine - administration & dosage</topic><topic>Fluvoxamine - adverse effects</topic><topic>Fluvoxamine - pharmacokinetics</topic><topic>Haloperidol - administration & dosage</topic><topic>Haloperidol - adverse effects</topic><topic>Haloperidol - pharmacokinetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Neurologic Examination - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenic Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DANIEL, D. G</creatorcontrib><creatorcontrib>RANDOLPH, C</creatorcontrib><creatorcontrib>LINNOILA, M</creatorcontrib><creatorcontrib>JASKIW, G</creatorcontrib><creatorcontrib>HANDEL, S</creatorcontrib><creatorcontrib>WILLIAMS, T</creatorcontrib><creatorcontrib>ABI-DARGHAM, A</creatorcontrib><creatorcontrib>SHOAF, S</creatorcontrib><creatorcontrib>EGAN, M</creatorcontrib><creatorcontrib>AHMED ELKASHEF</creatorcontrib><creatorcontrib>LIBOFF, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DANIEL, D. G</au><au>RANDOLPH, C</au><au>LINNOILA, M</au><au>JASKIW, G</au><au>HANDEL, S</au><au>WILLIAMS, T</au><au>ABI-DARGHAM, A</au><au>SHOAF, S</au><au>EGAN, M</au><au>AHMED ELKASHEF</au><au>LIBOFF, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coadministration of fluvoxamine increases serum concentrations of haloperidol</atitle><jtitle>Journal of clinical psychopharmacology</jtitle><addtitle>J Clin Psychopharmacol</addtitle><date>1994-10-01</date><risdate>1994</risdate><volume>14</volume><issue>5</issue><spage>340</spage><epage>343</epage><pages>340-343</pages><issn>0271-0749</issn><eissn>1533-712X</eissn><coden>JCPYDR</coden><abstract>Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7806690</pmid><doi>10.1097/00004714-199410000-00009</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-0749 |
| ispartof | Journal of clinical psychopharmacology, 1994-10, Vol.14 (5), p.340-343 |
| issn | 0271-0749 1533-712X |
| language | eng |
| recordid | cdi_crossref_primary_10_1097_00004714_199410000_00009 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Benztropine - administration & dosage Benztropine - adverse effects Benztropine - pharmacokinetics Biological and medical sciences Chronic Disease Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Drug toxicity and drugs side effects treatment Fluvoxamine - administration & dosage Fluvoxamine - adverse effects Fluvoxamine - pharmacokinetics Haloperidol - administration & dosage Haloperidol - adverse effects Haloperidol - pharmacokinetics Humans Male Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Neurologic Examination - drug effects Pharmacology. Drug treatments Psychiatric Status Rating Scales Schizophrenia - blood Schizophrenia - drug therapy Schizophrenic Psychology |
| title | Coadministration of fluvoxamine increases serum concentrations of haloperidol |
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