Coadministration of fluvoxamine increases serum concentrations of haloperidol

Coadministration of fluvoxamine increases serum concentrations of haloperidol

Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients a...

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Veröffentlicht in:Journal of clinical psychopharmacology 1994-10, Vol.14 (5), p.340-343
Hauptverfasser: DANIEL, D. G, RANDOLPH, C, LINNOILA, M, JASKIW, G, HANDEL, S, WILLIAMS, T, ABI-DARGHAM, A, SHOAF, S, EGAN, M, AHMED ELKASHEF, LIBOFF, S
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Benztropine - administration & dosage
Benztropine - adverse effects
Benztropine - pharmacokinetics
Biological and medical sciences
Chronic Disease
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Drug toxicity and drugs side effects treatment
Fluvoxamine - administration & dosage
Fluvoxamine - adverse effects
Fluvoxamine - pharmacokinetics
Haloperidol - administration & dosage
Haloperidol - adverse effects
Haloperidol - pharmacokinetics
Humans
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Neurologic Examination - drug effects
Pharmacology. Drug treatments
Psychiatric Status Rating Scales
Schizophrenia - blood
Schizophrenia - drug therapy
Schizophrenic Psychology
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Zusammenfassung:Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.
ISSN:0271-0749
1533-712X
DOI:10.1097/00004714-199410000-00009